When to pick
Pair it first with Leech and Impervious and test that relationship in the Beginner First Clear route. Regeneration cannot answer damage that kills the run before the next tick.
Read guideRegenerative Tissue
Regenerative Tissue public records: 3. Starting genetic coverage is 3/3, and numeric result coverage is 3/3. The most repeated related routes are Pressure 20 Complete, Vegan Pacifist, Chonk Body Slam.
Pair it first with Leech and Impervious and test that relationship in the Beginner First Clear route. Regeneration cannot answer damage that kills the run before the next tick.
Read guideThe links below support specific dated claims, mechanics, or player-route observations on this page; after a patch, use the current in-game text for exact values.
A source-linked Pressure 20 plus Extinction 4 clear record that points players toward a Prey survival shell: speed, dodge, terrain adaptation, smaller body, damage reduction, HP, regeneration, and poison resistance.
Read guideA high-pressure route record built around early Prey direction, Ruminant after the first boss, Burrower or Courting for survival windows, and charm or burrow control before the final boss.
Read guideA high-extinction discussion record that is useful for tracking Ability scaling, Stubborn, POI/mushroom loops, desert heat adaptation, and delayed-damage caveats around Impervious.
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