Practical use
- Current June 2026 public discussion points to the same practical rule many strong runs already follow: if an evolution is core to the route, take the usable version first instead of dying while waiting for the perfect color.
- A September 19–20 Steam exchange describes the upgrade control on the Evolution choice screen: spend 10 Mutagen to raise the current offers by one rarity tier. Players identify this as the action used for Elitist's 20-upgrade achievement, but the thread does not establish whether progress is counted per purchase or per offer shown; use the in-game counter.
- Patient matters because skipped level-ups improve the next evolution's rarity chance until a pick is taken, so the gene is strongest when you already know which breakpoint card you want.
- Ambivalent retains its size-based rarity trait and, since Version 1.1, also multiplies Mutagen gains for small builds. Choose size-changing evolutions according to the benefit your route needs.
- A later rarity upgrade appears to overwrite the current tier of that evolution, so legendary planning is most valuable on the final meaningful level of the card rather than every early click.
- Do not spend mutagen chasing rarity while food, movement, or boss-safe damage are still unsolved; a complete shell beats a shiny incomplete one.